Suboxone Drug Interactions

Suboxone is a multi-ingredient drug consisting of:

  • naloxone
  • buprenorphine

Interactions with each of its ingredients have been shown below:

naloxone is known to interact with the following drugs:

Click on a link below to view Drug-Drug Interactions with naloxone.

Major Interaction Major Interactions
Actiq, Alfenta, alfentanil, Astramorph PF, Avinza, butorphanol, codeine, codeine phosphate, codeine sulfate, Dalgan, Dazidox, Demerol HCl, dezocine, dihydrocodeine, Dilaudid, Dilaudid-5, Dilaudid-HP, Diskets, Dolophine, Doloral, Doloral Sirop, droperidol, Duragesic, Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-50, Duragesic-75, Duramorph PF, Endocodone, ETH-Oxydose, fentanyl, fentanyl topical, Fentora, heroin (Schedule I substance), hydrocodone, Hydromorph Contin, hydromorphone, hydromorphone extended release, Hydrostat IR, Inapsine, Infumorph, Ionsys, Kadian, Levo-Dromoran, levomethadyl acetate, levorphanol, M-Eslon, M-Oxy, M. O. S., meperidine, methadone, Methadose, morphine, morphine 24 hour extended release, morphine extended release, Morphine IR, Morphine LP Epidural, morphine preservative-free, Morphine Rapi-Ject, Morphitec, MS, MS Contin, MS/S, MSIR, nalbuphine, Nubain, Numorphan HCl, OMS, Opana, Opana ER, opium, Opium Deodorized, Oramorph SR, Orlaam, oxycodone, oxycodone extended release, OxyContin, Oxyfast, OxyIR, oxymorphone, oxymorphone extended release, Palladone, Palladone SR, Paregoric, pentazocine, Percolone, remifentanil, Rescudose, RMS, Roxanol, Roxanol 100, Roxanol-T, Roxicodone, Roxicodone Intensol, Stadol, Stadol NS, Statex, Sublimaze, Sufenta, sufentanil, Talwin Lactate, Ultiva

Moderate Interaction Moderate Interactions
Chem Mart Tramadol, Dromadol SR, Dromadol XL, GenRx Tramadol, Larapam SR, Terry White Chemists Tramadol, traMADOL, traMADOL extended release, Tramahexal, Tramahexal SR, Tramake, Tramake Insts, Tramal, Tramal SR, Tramedo, Ultram, Ultram ER, Zamadol, Zamadol 24hr, Zamadol Melt, Zamadol SR, Zydol, Zydol SR, Zydol XL

Minor Interaction Minor Interactions
A-Hydrocort, Colocort, Cortef, Cortenema, Cortifoam, fenfluramine, hydrocortisone, hydrocortisone acetate, hydrocortisone cypionate, hydrocortisone hemisuccinate, hydrocortisone sodium phosphate, Hydrocortisone Sodium Succinate, Hydrocortone, Hydrocortone Phosphate, Pondimin, Solu-Cortef

buprenorphine is known to interact with the following drugs:

Click on a link below to view Drug-Drug Interactions with buprenorphine.

Major Interaction Major Interactions
alvimopan, Budeprion SR, Budeprion XL, buPROPion, buPROPion 24 hour extended release, buPROPion extended release, Chem Mart Tramadol, Darvon, Darvon-N, Dromadol SR, Dromadol XL, droperidol, Entereg, furazolidone, Furoxone, GenRx Tramadol, GHB, Inapsine, iohexol, iopamidol, Iopamidol-370, isocarboxazid, Isovue-128, Isovue-200, Isovue-250, Isovue-300, Isovue-370, Isovue-M-200, Isovue-M-300, Larapam SR, Marplan, Matulane, metrizamide, Myelo-Kit, Nardil, Omnipaque 140, Omnipaque 180, Omnipaque 180 Redi-Unit, Omnipaque 210, Omnipaque 240, Omnipaque 240 Redi-Unit, Omnipaque 300, Omnipaque 350, Omnipaque Flexipak, Parnate, phenelzine, PP-Cap, procarbazine, propoxyphene, propoxyphene hydrochloride, propoxyphene napsylate, sodium biphosphate, sodium oxybate, Terry White Chemists Tramadol, traMADOL, traMADOL extended release, Tramahexal, Tramahexal SR, Tramake, Tramake Insts, Tramal, Tramal SR, Tramedo, tranylcypromine, Ultram, Ultram ER, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Xyrem, Zamadol, Zamadol 24hr, Zamadol Melt, Zamadol SR, Zyban, Zyban Advantage Pack, Zydol, Zydol SR, Zydol XL

Moderate Interaction Moderate Interactions
40 Winks, Abilify, Abilify Discmelt, Accolate, Accupril, acebutolol, Aceon, acetylcarbromal, Actiq, Adapin, Adgan, Adrenocot, Adrenocot L.A., Agenerase, AHist, Akineton HCl, alcohol, alcohol, ethyl, Aldactone, Aler-Dryl, Aler-Tab, Alfenta, alfentanil, alfuzosin, alfuzosin extended release, All Day Allergy, Aller-Chlor, Allergia-C, Allerhist-1, Allermax, Alphagan, Alphagan P, alprazolam, alprazolam extended release, Altace, Altaryl, Ambien, Ambien CR, amiloride, amitriptyline, amlodipine, amobarbital, amoxapine, amprenavir, Amrix, amyl nitrite, Amytal Sodium, Anafranil, Anergan 50, Antiflex, Antinaus 50, Antivert, Anturane, APO-Go, APO-Go Pen, Apokyn, apomorphine, apraclonidine ophthalmic, aprepitant, Apresoline, Aquachloral Supprettes, Aquazide H, Arfonad, aripiprazole, Artane, Asendin, Astramorph PF, Atacand, Atarax, atazanavir, atenolol, Ativan, Avapro, Aventyl HCl, Avinza, azatadine, B-Vex, baclofen, Banaril, Banflex, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Child Dye Free, Benadryl Childrens Allergy Fastmelt, Benadryl DF, Benadryl Dye Free Allergy, Benadryl Ultratab, Benahist-10, Benahist-50, bendroflumethiazide, Benicar, Benoject-50, Benzacot, benzthiazide, benztropine, Betapace, Betapace AF, Betapace AF(obsolete), betaxolol, bexarotene, Biaxin, Biaxin XL, Biaxin XL-Pak, Bidhist, biperiden, bisoprolol, Blocadren, Bonine, bosentan, Brevibloc, Brevital Sodium, brimonidine ophthalmic, Bromaphen, bromocriptine, bromodiphenhydramine, brompheniramine, brompheniramine extended release, BroveX, BroveX CT, Bubbli-Pred, bumetanide, Bumex, Busodium, BuSpar, BuSpar Dividose, busPIRone, butabarbital, butalbital, Butisol Sodium, butorphanol, Bydramine, C.P.M., Calan, Calan SR, Calm-Aid, candesartan, Capoten, captopril, Carbacot, carbamazepine, carbamazepine extended release, Carbatrol, carbetapentane, carbinoxamine, carbinoxamine extended release, Carbinoxamine PD, Carboxine, Cardene, Cardene IV, Cardene SR, Cardizem, Cardizem CD, Cardizem LA, Cardizem Monovial, Cardizem SR, Cardura, Cardura XL, Carduran, carisoprodol, Carozide, Cartia XT, carvedilol, carvedilol extended release, Cascor, Catapres, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3, Celexa, Celontin, Cerebyx, Cesamet, cetirizine, Chlo-Amine, chlophedianol, Chlor-Al Rel, Chlor-Mal, Chlor-Phen, Chlor-Phenit, Chlor-Trimeton, Chlor-Trimeton Allergy SR, chloral hydrate, chlordiazepoxide, chlormezanone, chlorothiazide, Chlorphen, chlorphenesin, chlorpheniramine, Chlorpheniramine (Allergy), chlorpheniramine 24 hour extended release, chlorpheniramine extended release, chlorproMAZINE, chlorproMAZINE extended release, ChlorTan, chlorthalidone, chlorzoxazone, cimetidine, citalopram, clarithromycin, clarithromycin extended release, clemastine, clomiPRAMINE, clonazepam, clonidine, clonidine topical, Clopine, clorazepate, clorazepate extended release, clotrimazole, clozapine, Clozapine Synthon, Clozaril, codeine, codeine phosphate, codeine sulfate, Codimal A, Cogentin, Comfort Pac with Cyclobenzaprine, Compazine, Compazine Spansule, Compound 374, Compoz Nighttime Sleep Aid, Compro, Comtan, conivaptan, Contac 12 Hour Allergy, Cophene B, Cordron NR, Coreg, Coreg CR, Corgard, Cortastat, Cortastat 10, Cortastat LA, Cotolone, Covera-HS, Cozaar, Crixivan, cyclizine, cyclobenzaprine, cyclobenzaprine extended release, Cymbalta, cyproheptadine, D-Vert, D.H.E. 45, Dailyhist-1, Dalalone, Dalalone D.P., Dalalone L.A., dalfopristin, Dalgan, Dalmane, danazol, Danocrine, Dantrium, Dantrium Intravenous, dantrolene, dasatinib, Dazidox, De-Sone LA, Decadron, Decadron 5-12 Pak, Decadron Phosphate, Injectable, Decadron-LA, Decaject, Decaject L.A., Dehydrated Alcohol, delavirdine, Demadex, Demadex I.V., Demerol HCl, Denzapine, Depacon, Depakene, Depakote, Depakote ER, Depakote Sprinkles, Depo-Predate (obsolete), DepoDur, Deponit, desflurane, desipramine, desvenlafaxine, Desyrel, Desyrel Dividose, Dexacen-4, Dexacort Phosphate in Respihaler, Dexacort-LA, Dexacorten, dexamethasone, dexamethasone acetate, Dexamethasone Intensol, dexamethasone sodium phosphate, Dexasone, Dexasone LA, dexbrompheniramine, dexmedetomidine, Dexone, Dexone LA, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, Dexpak Jr. Taperpak, dezocine, Di-Phen, Diaqua, Diaqua-2, Diastat, Diastat AcuDial, Diastat Pediatric, diazepam, diazoxide, Dibenzyline, dichloralphenazone, Diflucan, dihydrocodeine, dihydroergotamine, dihydroergotamine nasal, Dilacor XR, Dilantin, Dilantin Infatabs, Dilantin Kapseals, Dilantin-125, Dilatrate-SR, Dilaudid, Dilaudid-5, Dilaudid-HP, Diltia XT, diltiazem, diltiazem 24 hour extended release, diltiazem extended release, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltiazem Hydrochloride XT, Dimetane, Dimetane Extentab, Dimetapp Allergy, Dimetapp Allergy Liquigel, Diovan, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, diphenhydrAMINE, diphenhydrAMINE citrate, diphenhydrAMINE tannate, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Diprivan, Diskets, Diucardin, Diuril, Diuril Sodium, divalproex sodium, divalproex sodium extended release, Dizac, Dolophine, Doloral, Doloral Sirop, Doral, Doxadura, doxazosin, doxazosin extended release, doxepin, doxepin topical, doxylamine, DPH, Dramamine II, Dramamine Less Drowsy, Driminate II, dronabinol, duloxetine, Duraclon, Duragesic, Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-50, Duragesic-75, Duramorph PF, Dynacirc, Dynacirc CR, Dyrenium, Dytan, Dytuss, E-Mycin, E.E.S. Granules, E.E.S.-200, E.E.S.-400, E.E.S.-400 Filmtab, Ed Chlor-Tan, Ed ChlorPed, efavirenz, Effexor, Effexor XR, Efidac-24 Chlorpheniramine, Elavil, Emend, Emend 3-Day, Emend for Injection, enalapril, enalaprilat, Endep, Endocodone, enflurane, entacapone, Epitol, eprosartan, Equanil, Equetro, Ery-Tab, Eryc, EryPed, EryPed 200, EryPed 400, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, Erythrocot, erythromycin, erythromycin base, erythromycin estolate, erythromycin ethylsuccinate, erythromycin lactobionate, erythromycin stearate, escitalopram, Esidrix, Eskalith, Eskalith-CR, esmolol, estazolam, eszopiclone, ETH-Oxydose, ethanol, ethosuximide, ethotoin, Ethrane, Ethyl Alcohol, etravirine, Exna, Eze D.S., Ezide, FazaClo, felbamate, Felbatol, felodipine, felodipine extended release, fentanyl, fentanyl topical, Fentora, Fexmid, FK506, flavoxate, Flexeril, Flexoject, Flexon, Flo-Pred, fluconazole, Fluothane, fluoxetine, fluoxetine extended release, fluphenazine, fluphenazine decanoate, fluphenazine enanthate, fluphenazine hydrochloride, flurazepam, fluvoxamine, fluvoxamine extended release, Forane, Fortovase, fosaprepitant, fosinopril, fosphenytoin, Fulvicin P/G, Fulvicin U/F, furosemide, gabapentin, Gabarone, Gabitril, Genahist, Geodon, gingko, gingko biloba, ginkgo, ginkgo biloba, Gleevec, grepafloxacin, Grifulvin V, Gris-PEG, Grisactin 250, Grisactin 500, Grisactin Ultra, Griseofulicin, Griseofulvic, griseofulvin, griseofulvin microsize, griseofulvin ultramicrosize, guanethidine, halazepam, Halcion, Haldol, Haldol Decanoate, haloperidol, haloperidol decanoate, halothane, HCTZ, Hexadrol, Hexadrol Phosphate, Histaject, Histex CT, Histex I/E, Histex PD, Histex Pd 12, Hydeltra-T.B.A., Hydeltrasol, hydrALAZINE, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hydro Par, hydrochlorothiazide, hydrocodone, HydroDIURIL, hydroflumethiazide, Hydromorph Contin, hydromorphone, hydromorphone extended release, Hydrostat IR, hydrOXYzine, hydrOXYzine hydrochloride, hydrOXYzine pamoate, Hygroton, hypericum perforatum, Hyperstat, Hyrexin, Hytrin, Hyzine, Ilosone, Ilotycin Gluceptate, imatinib, Imdur, imipramine, imipramine pamoate, indapamide, Inderal, Inderal LA, indinavir, Infumorph, INH, InnoPran XL, Intelence, Invega, Invirase, Ionsys, Iopidine, irbesartan, ISDN, Ismelin, ISMO, Isochron, isoflurane, isoniazid, Isoptin, Isoptin I.V., Isoptin SR, Isordil, Isordil Tembids, Isordil Titradose, isosorbide dinitrate, isosorbide dinitrate extended release, isosorbide mononitrate, isosorbide mononitrate extended release, isradipine, isradipine extended release, itraconazole, J-Tan, J-Tan PD, Kadian, Kemadrin, Keppra, Keppra XR, Kerlone, Ketalar, ketamine, Ketek, Ketek Pak, ketoconazole, Key-Pred, Key-Pred SP, Klonopin, Klonopin Wafer, labetalol, Lamictal, Lamictal Blue, Lamictal CD, Lamictal Green, Lamictal Orange, lamotrigine, lapatinib, Largon, Lasix, levetiracetam, levetiracetam extended release, Levo-Dromoran, levocetirizine, levomethadyl acetate, levorphanol, LEVRIX, Lexapro, Librium, lindane topical, Lioresal, Lioresal Intrathecal, lisinopril, lithium, lithium carbonate, lithium carbonate extended release, lithium citrate, Lithobid, Lithonate, Lithotabs, Lo-Aqua, Lodrane 12 Hour, Lodrane 24, Lodrane XR, Loniten, Lopressor, Loqua, lorazepam, losartan, loxapine, Loxitane, Loxitane C, Loxitane IM, Lozol, Ludiomil, Luminal, Lunesta, Luvox, Luvox CR, Lyrica, M-Eslon, M-Oxy, M. O. S., Maolate, maprotiline, Marezine, Marinol, Mavik, MB-TAB, Mebaral, Meclicot, meclizine, Medicort, Medidex, Medidex LA, Medivert, Mellaril, Mellaril-S, Meni-D, meperidine, mephenytoin, mephobarbital, meprobamate, Meridia, Mesantoin, mesoridazine, metaxalone, methadone, Methadose, methocarbamol, methohexital, methoxyflurane, methsuximide, metoclopramide, metolazone, metoprolol, metoprolol extended release, metoprolol succinate, Metoprolol Succinate ER, metoprolol tartrate, mibefradil, Micardis, miconazole, Microzide, Midamor, midazolam, Mifeprex, mifepristone, Migranal, Millipred, Milontin, Miltown, Minipress, Minitran, minoxidil, Mio-Rel, Mirapex, mirtazapine, Mitran, Moban, moexipril, molindone, Monistat I.V., Monoket, Monopril, morphine, morphine 24 hour extended release, morphine extended release, Morphine IR, morphine liposomal, Morphine LP Epidural, morphine preservative-free, Morphine Rapi-Ject, Morphitec, MS, MS Contin, MS/S, MSIR, MY-E, Mycelex Troche, Mycobutin, Mykrox, Myolin, Mysoline, nabilone, nadolol, nalbuphine, naltrexone, Nasahist B, Naturetin-10, Naturetin-5, Navane, ND-Stat, nefazodone, nelfinavir, Nembutal, Nembutal Sodium, Nervine, Neupro, Neurontin, nevirapine, niCARdipine, niCARdipine extended release, Nightime Sleepaid, nilotinib, Niravam, nisoldipine, Nitrek, Nitro TD Patch-A, Nitro-Bid, Nitro-Bid IV, Nitro-Dur, Nitro-Par, Nitro-Time, Nitrocot, Nitrodisc, Nitrogard, nitroglycerin, Nitroglyn E-R, Nitrol, Nitrol Appli-Kit, Nitrolingual, Nitrolingual Duo Pack, Nitrong, Nitropress, nitroprusside, Nitroquick, Nitrostat, nitrous oxide, Nizoral, Norflex, Norflex Injectable, Normodyne, Norpramin, nortriptyline, Norvasc, Norvir, Norvir Soft Gelatin, Noxafil, NTG, Nu-Med, Nubain, Numorphan HCl, Nydrazid, Nytol Caplet, Nytol Maximum Strength, olanzapine, olmesartan, olopatadine nasal, OMS, Opana, Opana ER, opium, Opium Deodorized, Optimine, Oramorph SR, Orap, Orapred, Orapred ODT, OraVerse, Oretic, Orfro, Orlaam, Ormazine, orphenadrine, orphenadrine extended release, Orphenate, oxazepam, oxcarbazepine, oxycodone, oxycodone extended release, OxyContin, Oxyfast, OxyIR, oxymorphone, oxymorphone extended release, P-Tann, P-Tex, Palgic, paliperidone, Palladone, Palladone SR, Pamelor, Paradione, Paraflex, Parafon Forte DSC, Paral, paraldehyde, paramethadione, Pardryl, Paregoric, Parlodel, paroxetine, paroxetine extended release, paroxetine mesylate, Patanase, Paxarel, Paxil, Paxil CR, PBZ, PBZ-SR, PCE Dispertab, Pediapred, PediaTan, Pediatex, Pediatex 12, Pediox, Pediox-S, Peganone, pegvisomant, Pentazine, pentazocine, Penthrane, pentobarbital, Pentothal, Percolone, pergolide, Periactin, perindopril, Permax, Permitil, perphenazine, Pexeva, phenacemide, Phenadoz, Phenazine 50, Phenergan, Phenergan Fortis, phenobarbital, Phenoject-50, phenoxybenzamine, phensuximide, phentolamine, Phenurone, phenylbutazone, phenyltoloxamine, Phenytek, phenytoin, phenytoin extended release, Phenytoin Sodium, Prompt, pimozide, pindolol, Plendil, polythiazide, posaconazole, Posicor, pramipexole, prazosin, Precedex, Pred-Ject-50, Predacort 50, Predaject-50, Predalone 50, Predate-50, Predcor, Predicort RP, Predicort-50, prednisoLONE, prednisoLONE acetate, prednisoLONE sodium phosphate, prednisoLONE tebutate, pregabalin, Prelone, Pri-Cortin 50, Prialt, Priftin, Primethasone, primidone, Prinivil, Pristiq, Pro-Med, prochlorperazine, prochlorperazine extended release, Procot, procyclidine, Proglycem, Prograf, Prolixin, Prolixin Decanoate, Prolixin Enanthate, Promacot, promazine, promethazine, Promethegan, Prop-A-Tane, propiomazine, propofol, propranolol, propranolol extended release, Prorex, Prosom, protriptyline, Prozac, Prozac Weekly, Prudoxin, Q-Dryl, Q-Dryl A/F, QDALL AR, quazepam, Quenalin, quetiapine, quetiapine extended release, quinapril, ramipril, Rapamune, Rapiflux, Raxar, Reglan, Relaxazone, Remeron, Remeron SolTab, remifentanil, Remular, Remular-S, Renese, Repreve, Requip, ReQuip Follow on Pack, Requip Starter Kit, ReQuip Starter Pack, Requip XL, Rescriptor, Rescudose, Restoril, Revatio, ReVia, Reyataz, Rezine, Rezulin, Ridramin, rifabutin, Rifadin, Rifadin IV, rifampin, rifapentine, Rimactane, Risperdal, Risperdal Consta, Risperdal M-Tab, risperidone, ritonavir, RMS, Robaxin, Robaxin-750, Robimycin, Rohist, ropinirole, ropinirole extended release, rotigotine, Roxanol, Roxanol 100, Roxanol-T, Roxicodone, Roxicodone Intensol, RU-486, Ru-Vert-M, Saluron, saquinavir, saquinavir mesylate, Sarafem, Scot-Tussin Allergy Relief Formula, secobarbital, Seconal Sodium, Sectral, Selfemra, Serax, Serentil, Seroquel, Seroquel XR, sertraline, Serzone, sevoflurane, sibutramine, Siladryl, Siladryl Allergy, Siladryl DAS, Siladyl SA, sildenafil, Silphen Cough, Siltane, Simply Sleep, Sinequan, sirolimus, Skelaxin, Skelex, Sleep Tab II, Sleep Tabs, Sleep-ettes, Sleep-ettes D, Sleep-Eze-3, Sleepinal, sodium nitroprusside, sodium valproate, Sojourn, Solfoton, solotuss, Solurex, Solurex LA, Soma, Somavert, Sominex, Sominex Maximum Strength Caplet, Somnicaps, Somnote, Sonata, Sorbitrate, Sorine, sotalol, Sotalol Hydrochloride AF, Sotalol Hydrochloride AF(obsolete), Sparine, spironolactone, Sporanox, Sprycel, St. John's wort, Stadol, Stadol NS, Statex, Stavzor, Stelazine, Strifon Fort, Sublimaze, Sufenta, sufentanil, Sular, sulfinpyrazone, Suprane, Surmontil, Sustiva, tacrolimus, Tagamet, Tagamet HB, Talwin Lactate, Tanacof-XR, TanaHist-PD, Tao, Targretin, Tasigna, Tasmar, Tavist, Tavist Allergy, Tavist-1, Taztia XT, Tegretol, Tegretol XR, telithromycin, telmisartan, Temaril, temazepam, Tenormin, terazosin, Terrell, tetrabenazine, Teveten,